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1

Book reviews

Allcock, John, Shearman, Peter, Okey, Robin, Hash, Iraj, Halliday, Fred, Webber, Mark, Knight, Robert, Timmermann, Heinz, Ferdowsi, Mir, Swain, Nigel, Hill, Malcolm, Grahl, John, Howarth, Jolyon, Much

Journal:

Journal of Contemporary European Studies

Year:

1994

Language:

english

File:

PDF, 1.57 MB

english, 1994

2

Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as γ-secretase inhibitors

Tim Sparey, Earl Clarke, Joanne Hannam, Timothy Harrison, Andrew Madin, Mark Shearman, Bindi Sohal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 281 KB

english, 2008

3

Three period Homologs in Mammals: Differential Light Responses in the Suprachiasmatic Circadian Clock and Oscillating Transcripts Outside of Brain

Mark J Zylka, Lauren P Shearman, David R Weaver, Steven M Reppert

Journal:

Year:

1998

Language:

english

File:

PDF, 4.79 MB

english, 1998

4

New polymorphic microsatellite markers place the haemochromatosis gene telomeric to D6S105

Raha-Chowdhury, Ruma, Bowen, Derrick J., Stone, Caroline, Pointon, Jennifer J., Terwilliger, Joseph D., Shearman, Jeremy D., Robson, Kathryn J.H., Bomford, Adrian, Worwood, Mark

Journal:

Human Molecular Genetics

Year:

1995

Language:

english

File:

PDF, 549 KB

english, 1995

5

Synthesis and γ-Secretase Activity of APP Substrate-Based Hydroxyethylene Dipeptide Isosteres.

Alan Nadin, Andrew P. Owens, Jose L. Castro, Timothy Harrison, Mark S. Shearman

Journal:

Year:

2003

File:

PDF, 38 KB

2003

6

Aryl sulfones: a new class of γ-secretase inhibitors

Martin Teall, Paul Oakley, Timothy Harrison, Duncan Shaw, Euan Kay, Jason Elliott, Ute Gerhard, José L. Castro, Mark Shearman, Richard G. Ball, Nancy N. Tsou

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 143 KB

english, 2005

7

Cyclic sulfamide γ-secretase inhibitors

Tim Sparey, Dirk Beher, Jonathan Best, Mirlinda Biba, José L. Castro, Earl Clarke, Joanne Hannam, Timothy Harrison, Huw Lewis, Andrew Madin, Mark Shearman, Bindi Sohal, Nancy Tsou, Christopher Welch,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 205 KB

english, 2005

8

The geminal dimethyl analogue of Flurbiprofen as a novel Aβ42 inhibitor and potential Alzheimer’s disease modifying agent

Nicholas Stock, Benito Munoz, Jonathan D.J. Wrigley, Mark S. Shearman, Dirk Beher, James Peachey, Toni L. Williamson, Gretchen Bain, Weichao Chen, Xiaohui Jiang, René St-Jacques, Peppi Prasit

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 163 KB

english, 2006

9

3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity

Richard A. Jelley, Jason Elliott, Karl R. Gibson, Timothy Harrison, Dirk Beher, Earl E. Clarke, Huw D. Lewis, Mark Shearman, Jonathan D.J. Wrigley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 123 KB

english, 2006

10

Quinazolinones as γ-secretase modulators

Christian Fischer, Sanjiv Shah, Bethany L. Hughes, George N. Nikov, Jamie L. Crispino, Richard E. Middleton, Alexander A. Szewczak, Benito Munoz, Mark S. Shearman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.22 MB

english, 2011

11

A comparative assessment of γ-secretase activity in transgenic and non-transgenic rodent brain

Julian L. Goggi, Huw D. Lewis, Joanie Mok, Tim Harrison, Mark S. Shearman, John R. Atack, Jonathan D. Best

Journal:

Journal of Neuroscience Methods

Year:

2006

Language:

english

File:

PDF, 366 KB

english, 2006

12

Catalytic activity of fullerenes for hydrocracking coal extracts

Sheng-Fu Zhang, Jim R. Shearman, Mark Domin, Maria-Jesus Lazaro, Alan A. Herod, Rafael Kandiyoti

Journal:

Year:

1997

Language:

english

File:

PDF, 812 KB

english, 1997

13

Quantitation of amyloid-β peptides in biological milieu using a novel homogeneous time-resolved fluorescence (HTRF) assay

Earl E. Clarke, Mark S. Shearman

Journal:

Journal of Neuroscience Methods

Year:

2000

Language:

english

File:

PDF, 153 KB

english, 2000

14

Synthesis and γ-secretase activity of APP substrate-based hydroxyethylene dipeptide isosteres

Alan Nadin, Andrew P. Owens, José L. Castro, Timothy Harrison, Mark S. Shearman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 180 KB

english, 2003

15

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from γ-secretase

Janelle Nunan, Mark S. Shearman, Frédéric Checler, Roberto Cappai, Geneviève Evin, Konrad Beyreuther, Colin L. Masters, David H. Small

Journal:

Year:

2001

Language:

english

File:

PDF, 602 KB

english, 2001

16

The effect of HFE mutations on serum ferritin and transferrin saturation in the Jersey population

Alison T. Merryweather-Clarke, Mark Worwood, Lisa Parkinson, Chris Mattock, Jennifer J. Pointon, Jeremy D. Shearman, Kathryn J. H. Robson

Journal:

British Journal of Haematology

Year:

1998

Language:

english

File:

PDF, 452 KB

english, 1998

17

The Intracellular Component of Cellular 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) Reduction Is Specifically Inhibited by β-Amyloid Peptides

Mark S. Shearman, Stuart R. Hawtin, Vipula J. Tailor

Journal:

Journal of Neurochemistry

Year:

1995

Language:

english

File:

PDF, 1.27 MB

english, 1995

18

Generation of C-terminally truncated amyloid-β peptides is dependent on γ-secretase activity

Dirk Beher, Jonathan D. J. Wrigley, Andrew P. Owens, Mark S. Shearman

Journal:

Journal of Neurochemistry

Year:

2002

Language:

english

File:

PDF, 1.23 MB

english, 2002

19

Lack of evidence for a role of endorphinergic mechanisms in mediating a discriminative stimulus produced by diazepam in rats

Gary T. Shearman, Mark J. Millan, Albert Herz

Journal:

Psychopharmacology

Year:

1982

Language:

english

File:

PDF, 274 KB

english, 1982

20

A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core

Stephen J. Lewis, Adrian L. Smith, Joseph G. Neduvelil, Graeme I. Stevenson, Matthew J. Lindon, A. Brian Jones, Mark S. Shearman, Dirk Beher, Earl Clarke, Jonathan D. Best, James E. Peachey, Timothy H

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 362 KB

english, 2005

21

3,4-Fused cyclohexyl sulfones as γ-secretase inhibitors

Duncan Shaw, Jonathan Best, Kevin Dinnell, Alan Nadin, Mark Shearman, Christine Pattison, James Peachey, Michael Reilly, Brian Williams, Jonathan Wrigley, Timothy Harrison

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 153 KB

english, 2006

22

Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in a Drosophila model of Alzheimer’s disease

Thomas Rival, Richard M. Page, Dhianjali S. Chandraratna, Timothy J. Sendall, Edward Ryder, Beinan Liu, Huw Lewis, Thomas Rosahl, Robert Hider, L. M. Camargo, Mark S. Shearman, Damian C. Crowther, D

Journal:

European Journal of Neuroscience

Year:

2009

Language:

english

File:

PDF, 617 KB

english, 2009

23

Synaptosomal Protein Kinase C Subspecies: B. Down-Regulation Promoted by Phorbol Ester and Its Effect on Evoked Norepinephrine Release

Tomiichiro Oda, Mark S. Shearman, Yasutomi Nishizuka

Journal:

Journal of Neurochemistry

Year:

1991

Language:

english

File:

PDF, 817 KB

english, 1991

24

Synaptosomal Protein Kinase C Subspecies: A. Dynamic Changes in the Hippocampus and Cerebellar Cortex Concomitant with Synaptogenesis

Mark S. Shearman, Tetsutaro Shinomura, Tomiichiro Oda, Yasutomi Nishizuka

Journal:

Journal of Neurochemistry

Year:

1991

Language:

english

File:

PDF, 1.08 MB

english, 1991

25

Conserved residues within the putative active site of γ-secretase differentially influence enzyme activity and inhibitor binding

Jonathan D. J. Wrigley, Emma J. Nunn, Omar Nyabi, Earl E. Clarke, Peter Hunt, Alan Nadin, Bart De Strooper, Mark S. Shearman, Dirk Beher

Journal:

Journal of Neurochemistry

Year:

2004

Language:

english

File:

PDF, 205 KB

english, 2004

26

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

Jun Wang, Dirk Beher, Andrew C. Nyborg, Mark S. Shearman, Todd E. Golde, Alison Goate

Journal:

Journal of Neurochemistry

Year:

2006

Language:

english

File:

PDF, 334 KB

english, 2006

27

MK-801, an Excitatory Amino Acid Antagonist, Does Not Improve Neurologic Outcome Following Cardiac Arrest in Cats

Fleischer, Jerry E., Tateishi, Akio, Drummond, John C., Scheller, Mark S., Grafe, Marjorie R., Zornow, Mark H., Shearman, Gary T., Shapiro, Harvey M.

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

1989

Language:

english

File:

PDF, 429 KB

english, 1989

28

Humidified high flow nasal cannulae: Current practice in Australasian nurseries, a survey

Judith L Hough, Andrew D Shearman, Luke A Jardine, Mark W Davies

Journal:

Journal of Paediatrics and Child Health

Year:

2012

Language:

english

File:

PDF, 184 KB

english, 2012

29

Endoproteolysis of the ER Stress Transducer ATF6 in the Presence of Functionally Inactive Presenilins

Harald Steiner, Edith Winkler, Mark S. Shearman, Ron Prywes, Christian Haass

Journal:

Neurobiology of Disease

Year:

2001

Language:

english

File:

PDF, 118 KB

english, 2001

30

Cytotoxicity of Prion Protein Peptide (PrP106–126) Differs in Mechanism from the Cytotoxic Activity of the Alzheimer's Disease Amyloid Peptide, Aβ25–35

James Hope, Mark S. Shearman, Helen C. Baxter, Angela Chong, Sharon M. Kelly, Nicholas C. Price

Journal:

Neurodegeneration

Year:

1996

Language:

english

File:

PDF, 448 KB

english, 1996

31

The common structure and activities of four subspecies of rat brain protein kinase C family

Ushio Kikkawa, Kouji Ogita, Yoshitaka Ono, Yoshinori Asaoka, Mark S. Shearman, Tomoko Fujii, Katsuhiko Ase, Kazuo Sekiguchi, Koichi Igarashi, Yasutomi Nishizuka

Journal:

Year:

1987

Language:

english

File:

PDF, 503 KB

english, 1987

32

Isolation of protein kinase C subspecies from a preparation of human T lymphocytes

Mark S. Shearman, Nicola Berry, Tomiichiro Oda, Katsuhiko Ase, Ushio Kikkawa, Yasutomi Nishizuka

Journal:

Year:

1988

Language:

english

File:

PDF, 599 KB

english, 1988

33

Activation of a brain-specific protein kinase C subspecies in the presence of phosphatidylethanol

Yoshinori Asaoka, Ushio Kikkawa, Kazuo Sekiguchi, Mark S. Shearman, Yoshiyuki Kosaka, Yoshio Nakano, Tadashi Satoh, Yasutomi Nishizuka

Journal:

Year:

1988

Language:

english

File:

PDF, 362 KB

english, 1988

34

Selective activation of the γ-subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites

Mark S. Shearman, Zvi Naor, Kazuo Sekiguchi, Akira Kishimoto, Yasutomi Nishizuka

Journal:

Year:

1989

Language:

english

File:

PDF, 388 KB

english, 1989

35

Protein kinase C subspecies in adult rat hippocampal synaptosomes Activation by diacylglycerol and arachidonic acid

Mark S. Shearman, Tetsutaro Shinomura, Tomiichiro Oda, Yasutomi Nishizuka

Journal:

Year:

1991

Language:

english

File:

PDF, 326 KB

english, 1991

36

Protein kinase C activation enhances the delayed rectifier potassium current in guinea-pig heart cells

Noritsugu Tohse, Masaki Kameyama, Kazuo Sekiguchi, Mark S. Shearman, Morio Kanno

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1990

Language:

english

File:

PDF, 863 KB

english, 1990

37

Sulfonated dyes attenuate the toxic effects of β-amyloid in a structure-specific fashion

Scott J. Pollack, Isobel I.J. Sadler, Stuart R. Hawtin, Vipula J. Tailor, Mark S. Shearman

Journal:

Neuroscience Letters

Year:

1995

Language:

english

File:

PDF, 337 KB

english, 1995

38

Novel aspects of accumulation dynamics and Aβ composition in transgenic models of AD

Huw D Lewis, Dirk Beher, David Smith, Louise Hewson, Natalie Cookson, David S Reynolds, Gerard R Dawson, Michael Jiang, Lex H.T Van der Ploeg, Su Qian, Thomas W Rosahl, Raj N Kalaria, Mark S Shearman

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 344 KB

english, 2004

39

Differential expression of multiple protein kinase C subspecies in rat central nervous tissue

Mark S. Shearman, Zvi Naor, Ushio Kikkawa, Yasutomi Nishizuka

Journal:

Biochemical and Biophysical Research Communications

Year:

1987

Language:

english

File:

PDF, 653 KB

english, 1987

40

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

François G. Gervais, Daigen Xu, George S. Robertson, John P. Vaillancourt, Yanxia Zhu, JingQi Huang, Andréa LeBlanc, David Smith, Michael Rigby, Mark S. Shearman, Earl E. Clarke, Hui Zheng, Leonardus

Journal:

Year:

1999

Language:

english

File:

PDF, 583 KB

english, 1999

41

mCRY1 and mCRY2 Are Essential Components of the Negative Limb of the Circadian Clock Feedback Loop

Kazuhiko Kume, Mark J Zylka, Sathyanarayanan Sriram, Lauren P Shearman, David R Weaver, Xiaowei Jin, Elizabeth S Maywood, Michael H Hastings, Steven M Reppert

Journal:

Year:

1999

Language:

english

File:

PDF, 362 KB

english, 1999

42

A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock

Xiaowei Jin, Lauren P. Shearman, David R. Weaver, Mark J. Zylka, Geert J. De Vries, Steven M. Reppert

Journal:

Year:

1999

Language:

english

File:

PDF, 359 KB

english, 1999

43

Direct analysis of γ-secretase activity in SH-SY5Y neuroblastoma cells identifies the Golgi as the main compartment of amyloid-β(X-40) peptide. Generation

Dirk Beher, Yue-Ming Li, Stephen J. Gardell, Mark S. Shearman

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 197 KB

english, 2000

44

Specific APP γ-secretase inhibitors do not prevent Notch signalling in vivo

Mark S. Shearman, Caroline Beck, Jose L. Castro, Jonathan Slack

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 194 KB

english, 2000

45

Age-dependent deficit in late-phase LTP in the hippocampus of human APP695SWE X PS1A246E double transgenic mice

Frederick M. Kuenzi, Robin A. Morton, Steven M. Fitjohn, Thomas Rosahl, Huw Lewis, Mark S. Shearman, Merck Sharp, Guy R. Seabrook, Merck Sharp

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 173 KB

english, 2000

46

The impact of cerebrovascular disease on Alzheimer pathology in the elderly

Raj N. Kalaria, Huw Lewis, Natalie J. Cookson, Mark Shearman

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 329 KB

english, 2000

47

γ-Secretase: characterization and implication for Alzheimer disease therapy

Min Xu, Ming-Tain Lai, Qian Huang, Jillian DiMuzio-Mower, José L Castro, Timothy Harrison, Alan Nadin, Joseph G Neduvelil, Mark S Shearman, Jules A Shafer, Stephen J Gardell, Yue-Ming Li

Journal:

Neurobiology of Aging

Year:

2002

Language:

english

File:

PDF, 298 KB

english, 2002

48

Impairment in hippocampal long-term potentiation in mice under-expressing the Alzheimer's disease related gene presenilin-1

Robin A. Morton, Frederick M. Kuenzi, Stephen M. Fitzjohn, Thomas W. Rosahl, David Smith, Hui Zheng, Mark Shearman, Graham L. Collingridge, Guy R. Seabrook

Journal:

Neuroscience Letters

Year:

2002

Language:

english

File:

PDF, 160 KB

english, 2002

49

Two period Homologs: Circadian Expression and Photic Regulation in the Suprachiasmatic Nuclei

Lauren P. Shearman, Mark J. Zylka, David R. Weaver, Lee F. Kolakowski Jr., Steven M. Reppert

Journal:

Year:

1997

Language:

english

File:

PDF, 499 KB

english, 1997

50

Molecular Analysis of Mammalian Timeless

Mark J Zylka, Lauren P Shearman, Joel D Levine, Xiaowei Jin, David R Weaver, Steven M Reppert

Journal:

Year:

1998

Language:

english

File:

PDF, 496 KB

english, 1998

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